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KMID : 0377519910160040495
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Chung-Ang Journal of Medicine
1991 Volume.16 No. 4 p.495 ~ p.507
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Effects of Papaverine on the Membrane Currents of Single Ventricular Myocytes
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Abstract
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Ventricular `myocytes of guinea -pig were isolated by means of collagenase digestion in order to investigate the ´effects of papaverine on the membrane currents in them. After formation of a gigaseal withpatch microelectrodes, membrane currents were recorded from single ventricular myocytes in a whole cell mode of patch-clamp technique.
For membrane currents recording, electrodes were filled with Cs-solution.
Results were as follows:
1. Slow inward calcium currents was reduced by papaverine dose-dependently.
2. No significant changes were observed on the steady-state inactivation.
3. Recovery time of the calcium currents prolonged in high concencial papaverine.
4. Fast inward sodium currents showed no noticeable changes with papaverine treatment. From these results, it` is strongly suggested that the effects of _ papaverine on the membrane cur-
rents in the single ventricular myocytes may be attributable to its antagonistic action on the calci-
um channel rather than its inhibitory effect on the phosphodiesterase activity.
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